Abstract
Rheumatoid arthritis is an autoimmune disease with a strong association with DR4 in many populations. In the Thai population, rheumatoid arthritis is associated with DRB1∗0405. To evaluate the role of polymorphism in TAP and HLA-DM genes, which are important in antigen processing and presentation in predisposition to rheumatoid arthritis, 82 Thai patients with rheumatoid arthritis and 100 unrelated normal controls were studied. TAP and HLA-DM typing was performed by ARMS-PCR and PCR-SSO method, respectively. There was no difference in the distribution of TAP1, TAP2, DMA, and DMB genes between the patients and controls. This study suggested that TAP and HLA-DM genes do not confer susceptibility to rheumatoid arthritis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
