Abstract
The goal of this study is to evaluate the effect of Doxorubicine chemotherapy on some biochemical and hematological markers in female cancer's patients. 22 cases of women cancer and control were chosen, Blood samples were collected from them and lipid profile, creatinine, urea levels and enzyme activities were measured. Also, erythrocyte and leucocyte line levels in blood was measured. Results of biochemical parameters revealed that a significant increase in serum lipid profile, creatinine level, LDH, GOT, GPT and GGT activities and no significant change in serum urea level in women with cancer compared to controls. On the other hand, Results of the haematological analysis show that RBC, HGB, HCT and lymphocyte (p <0.01) level are significant decreased in patients compared to control group and no significant change in WBC, Neutrophil , Monocyte , Eosinophil and basophile in patients compared to control group. In conclusion, the present study suggests that doxorubicin affect some biochemical and hematological marker of cardiac function indicating the cardiotoxic as a side effect of this treatment in cancer patients.
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