Abstract
Inability to grow at elevated temperature (temperature sensitivity or ts phenotype) is an important characteristic of wild-type ( wt) viruses. Analysis of our data along with published data revealed that the ts phenotype of wt influenza viruses isolated in different years demonstrated a cyclical pattern. New antigenic (drift) variants usually demonstrated a non- ts phenotype while many isolates exhibited a pronounced ts phenotype at the end of the drift variant circulation. Live attenuated cold-adapted ( ca) reassortant influenza vaccines (CAIV) are based on reassortment between well-characterized ca donor strains and current wt viruses. In this study, we evaluated the role of the ts phenotype of wt parent viruses in the manifestation of immunogenicity of CAIV in humans.
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