Analysis of Serum Insulin, Cortisol, and Glucose Levels in the Settlement Inhabitants of the Yamalo-Nenets Autonomous Okrug

Abstract

We studied the concentrations of insulin, cortisol and glucose in blood serum of two groups of inhabitants of the Yamalo-Nenets Autonomous okrug (YaNAO) settlements (indigenous population and those who arrived from Central Russia). The insulin level in all groups (in indigenous and non-native population, men and women) was above 9.0 μIU/mL. The insulin level in non-native women and men was higher than that in the indigenous people by 19% and 26%, respectively. The tendency of increasing insulin level with age was revealed in both the indigenous and non-native inhabitants. The highest level of insulin and glucose was observed in Samburg and Kharampur settlements; the lowest, in Gyda settlement. The cortisol level was higher in men than in women. The reduced cortisol/insulin index was observed in both groups of men. A most significant decrease in the cortisol/insulin index and an increase in HOMA–IR index were observed in nonnative men and women as compared with indigenous population. These data confirm the likelihood of the metabolic syndrome and type 2 diabetes mellitus in the YaNAO population, especially among non-native inhabitants.