Abstract
Objective To explore the relationship between atopic dermatitis (AD) and IgE,intedeukin (IL)-4 and IL-18 levels in maternal serum and umbilical cord blood.Methods A total of 921 mother-newborn pairs were recruited to a birth cohort during 2009-2011 through a questionnaire survey.Venous blood samples were collected from the mothers during birth hospitalization,and umbilical cord blood samples from the newborns at birth.All of these blood samples were cryopreserved.Thirty-five infants,who were diagnosed with AD during follow up at 12 and 24 months after birth,with their mothers served as the patient group; 35 infants without AD were selected randomly from the remaining infants,and served as the control group with their mothers.Enzyme-linked immunosorbent assay (ELISA) was performed to detect the levels of IgE,IL-4 and IL-18 in serum samples from the mothers of these 70 infants as well as in their umbilical cord blood samples,so as to evaluate the roles of these indexes in predicting the occurrence of AD.Results Compared with the control group,the patient group showed higher total IgE levels in maternal serum ((425.34 ± 278.38) vs.(87.12 ± 47.48) IU/ml,t =7.29,P＜ 0.01) and umbilical cord blood ((418.23 ± 256.76) vs.(81.77 ± 45.26) IU/ml,t =7.88,P ＜ 0.01).Increased IL-4 level was also observed in maternal serum ((316.28 ± 80.92) vs.(188.79 ± 61.92) ng/L,t =25.77,P ＜ 0.01) and umbilical cord blood ((356.73 ± 91.01) vs.(191.45 ± 73.65) ng/L,t =18.90,P＜ 0.01) in the patient group compared with the control group.The IL-8 level was significantly higher in maternal serum in the patient group than in the control group ((425.38 ± 49.36) vs.(141.7 ± 29.91) ng/L,t =42.73,P ＜ 0.01),but similar in umbilical cord blood between the two groups (P ＞ 0.05).Conclusion Total IgE and IL-4 levels in maternal serum and umbilical cord blood as well as IL-18 level in maternal serum are related to the occurrence of childhood AD. Key words: Dermatitis, atopic; Immunoglobulin E; Interleukin-18; Interleukin-4; Cord blood
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
