Abstract
Myostatin (encoded by MSTN gene) also called GDF-8, belongs to the TGF-β super family of growth and differentiation factors. Myostatin protein acts as a strong inhibitor of muscle formation. In Thoroughbred horses MSTN polymorphism g.66493737T>C is associated with racing phenotypes and body compositions. The aim of the present study was to examine the occurrence of MSTN variants among four polish breeds (in total 348 horses): Arabians, Polish Konik, Hucul and Polish Heavy Draft, distribution of haplotypes among these breeds, and finally influence of investigated polymorphisms on height at the withers in Arabian horses (n=96). Results showed occurrence of five SNPs: g.66495826T>C, g.66495696T>C, g.66493737T>C, g.66495254C>T, g.66490010T>C previously described. Furthermore, influence of investigated polymorphisms on height at the withers during growth in Arabian horses revealed significant impact of g.66495696T>C polymorphism on height at the withers at the first 12h of life. On the other hand, heterozygous foals are higher and this trend has been observed from six to 36 month of life.
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