Abstract
Capillary gas chromatography combined with electron-capture detection (GC—ECD) was applied to the detection and quantitation of N- n-propylnorapomorphine (NPA) and related compounds in serum and tissue using trifluoroacetyl (TFA) derivatives. The detection limits for NPA using GC—ECD of TFA derivative extend into the subpicogram level, but quantitation in serum was limited to levels of 100 ng/ml due to matrix interferences. The method was applied to the analysis of NPA in rat serum after administration of a moderate dose of the drug and was applied to the detection of NPA in rat brain after the peripheral administration of (—)10,11-methylenedioxy-N- n-propylnoraporphine (MDO-NPA). These results support previous proposals that MDO-NPA is a prodrug of NPA, which acts at cerebral dopamine-receptors.
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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