Analysis of influencing factors of quality of life and anxiety of non-small cell lung cancer patients before and after chemotherapy

Abstract

Objective This study aims to observe the changes in quality of life as well as the anxiety among non-small cell lung cancer patients before and after chemotherapy,and to explore the effect of chemotherapy on quality of life and anxiety.Methods EORTC QLQ-C30,and SAS were used to investigate clinical treatment effect before chemotherapy,one week after two courses of chemotherapy,and one week after four courses of chemotherapy.Results Before chemotherapy,fatigue and dyspnoea scores were high,the rate of anxiety was 58％,while the SAS score was (49.7±5.8).Anxiety was found to be positively correlated with insomnia.After two courses of chemotherapy,dyspnoea scores decreased,while insomnia and appetite loss scores increased.The difference was statistically significant.After four courses of chemotherapy,the physical,role,emotional,and social function scores decreased,while the nausea and vomiting,appetite loss,constipation,and financial impact scores increased.The difference was statistically significant,anxiety was signifcantly positively correlated with fatigue,insomnia and constipation.Conclusions A number of patients have experienced symptom relief,but during chemotherapy,the patients had significant anxiety.Thus,quality of life decreased.The quality of life and emotions of non-small cell lung cancer patients should be evaluated,and positive psychological intervention should be given to improve quality of life. Key words: Non-small cell lung cancer; Chemotherapy; Quality of life; Anxiety