Analysis of IgM antibody of ABO blood group in infants from 0 to 6 months in Xiamen area

Abstract

Objective To explore the coincidence rates of positive and reverse blood group of infants younger than six months in Xiamen area in recent years, and to analyze the difference of anti-A or anti-B antibody in infants of different age groups and different ABO blood groups. Methods 2 993 hospitalized infants from 0 to 6 months in five hospitals of Xiamen area were selected. EDTA-K2 anticoagulant blood samples were collected. Micro-column gel agglutination assay was used in ABO blood group. All the infants were divided into six groups, which aged from 0-7 days, 8-14 days, 15-31 days, 1-2 months, 3-4 months and 5-6 months. The coincidence rates of positive and reverse blood group of each group were compared. Results Of the 2 993 infants, 303 cases were AB type. The coincidence rates of positive and reverse blood group of the other infants which aged from 0-7 days, 8-14 days, 15-31 days, 1-2 months, 3-4 months and 5-6 months were 57.0%, 61.0%, 63.0%, 71.8%, 84.9% and 91.0%, respectively. The coincidence rates of positive and reverse blood group between different blood groups had no statistically significant difference(χ2=0.842, P=0.657). The coincidence rates of positive and reverse blood group had statistically significant difference among different age groups(χ2=185.683, P<0.05). Conclusion The IgM antibody of ABO blood group is detected in infants younger than six months. Positive and reverse blood group is necessary in ABO blood group identification of infants to guarantee the safety clinical blood transfusion. Key words: ABO blood-group system; Immunoglobulin M; Infant