Abstract
Sera from 11 healthy non-smokers and 12 healthy smokers as well as sera from 23 patients suffering from adenocarcinoma of the bowel were analysed for carcinoembryonic antigen (CEA) binding proteins. The methods used were affinity chromatography on CEA-agarose columns, follwed by an 125I -CEA binding assay with rabbit antihuman immune globulin (Ig) G as the precipitating antibody. The serum preparations of healthy non-smokers ( N = 11) bind 125I -CEA up to 1%. Seven of the sera from smokers ( N = 12) and 7 of the sera from patients with resectable colorectal cancers ( N = 12) show binding up to 10%. On the basis of the binding assay used, it is concluded that human IgG binds the 125I -CEA. The binding did not correlate with antiblood group antibodies. Although some findings may indicate a possible immunogenicity of CEA in man, cross-reactions of antibodies against antigens similar to CEA seem to be more likely to account for the weakness of the 125I -CEA binding.
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