Analysis of hemodynamic parameters on two-layered blood flow in a curved artery

Abstract

Arterial stenosis is the thickening of the arterial wall due to the growth of aberrant tissues that prevent adequate blood flow in the human circulatory system and induces cardiovascular diseases. Mild stenosis, may lead to serious or permanent damage if remains uncured. There are differences in the curvature response and material composition between the outer layers and the core. There are several locations in blood vessels where they are curved, which affects the blood flow and shear stress. The Navier-Stokes equation in the cylindrical polar coordinate system has been extended by incorporating curvature term in two-layered blood flow along the axial direction with appropriate boundary conditions. Mathematical expressions for hemodynamic parameters such as velocity profile, volumetric flow rate, pressure drop, and shear stress have been calculated analytically in the case of a curve artery with stenosis. Moreover, we have analyzed the effect of stenosis on different hemodynamic parameters with the variation of core and peripheral-layer viscosity and curvature. Flow quantities are affected by the habitancy of stenosis and stipulate different blood flow behavior in both layers in the case of curved artery. This modeling technique may help researchers in medicine, mathematical biology, and bio-engineering.