Analysis of G:C>T:A, G:C>A:T and G:C>C:G mutations in the TP53 gene in women with and without breast cancer in the long term period after chronic radiation exposure

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This paper presents the results of the analysis of mutations such as G:CT:A, G:CA:T and G:CC:G in the TP53 gene in peripheral blood cells in women affected by chronic radiation exposure with breast cancer (24 persons) and without breast cancer (17 persons). 17 different variants representing single nucleotide substitutions were registered. The differences in the frequencies of carriers of the detected variants between the comparison and the main group were not statistically significant. All detected variants were present in the IARC TP53 database and had no clinical significance as “pathogenic.” Despite the absence of statistically significant differences, the question of the effect of chronic low dose rate exposure on the frequency of mutations in the TP53 gene remains open and requires further research involving a greater amount of data.