Abstract
Purpose/Objective: Extracranial stereotactic radiosurgery (ESR) is being widely investigated, and encouraging tumor control rates have been observed. However, variations in dose prescriptions between institutions and inherent inter-patient variability render it difficult to construct accurate dose-response relationships. These limitations could impede efforts to conduct multi-center clinical trials. Equivalent uniform dose (EUD) formalism was applied to describe the differences in biologic effect among clinically applied methods of ESR. Additionally, since the typical dose per fraction in ESR is much higher than conventional radiotherapy and most cells of average radiosensitivity will be killed, the implications of observed tumor control rates with respect to the fraction of highly resistant cells are explored by analyzing tumor control probability (TCP).
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