Analysis of bloodstream infections and their antimicrobial susceptibility pattern in a COVID-19 dedicated centre: Six months hospital-based study

Abstract

COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been impacting the life and economy across the globe since December 2019 and has caused major disruptions worldwide. The COVID-19 pandemic had resurfaced in India in the form of a hard-hitting second wave around April 2021Blood stream infections (BSI) are one of the most significant causes of morbidity and mortality in tertiary care hospitals amongst COVID-19 patients.: This study was conducted to assess the bloodstream infections and their antimicrobial susceptibility pattern of in a COVID-19 dedicated tertiary care centre.This retrospective observational study was carried out from April 2021 to September 2021 in a bacteriology laboratory, department of Microbiology, at a dedicated COVID-19 tertiary care centre. Blood Cultures of all COVID-19 confirmed cases were sought for and Bacterial Identification and Antimicrobial Susceptibility were performed as per the standard guidelines.A total of4200 blood culture samples from COVID-19 positive patients were received during April 2021- September 2021 for analyses of microorganisms and antimicrobial susceptibility profile of blood stream infection. 16.9% samples were grew significant bacteria. Gram-positive isolates outnumbered than Gram-negative organisms (1.36:1). Amongst Gram-negative microorganisms, most commonly isolated bacteria were . (11.8%) and amongst gram-positive organisms, (n=348; 48.9%) was most commonly isolated.The blood culture positivity along with their antimicrobial susceptibility is the need of the hour in order to aid hospitals to formulate and implement antimicrobial stewardship guidelines