Abstract
(1) The methods available for assessment of the regulatory features of dose-response relationships that do not conform to the Hill equation are considered, and the sensitisation index S i introduced. (2) The value of determining S i is assessed using lipolytic dose-response relationships yielded by β-adrenergic agonists both alone and in the presence of their specific antagonists [D. M. F. Cooper and J. I. Davies, Biochem. Pharmac. 31, 721 (1982)]. (3) It is shown that where the Hill equation is fitted to relationships between l-noradrenaline concentration and lipolysis, the high value obtained for the Hill coefficient (1.69) is artefactual. (4) By fitting a rational quadratic model and evaluating S i , a solution is obtained ( S i (max), 1.02) which is free of this artefact. (5) The relationship between the results obtained by analysis of dose-response curves and direct binding of catecholamine analogues to membrane receptors is discussed.
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