Abstract
ABC transporters are a large family of membrane proteins that transport chemically diverse substrates across the cell membrane. Disruption of transport mechanisms mediated by ABC transporters causes the development of various diseases, including atherosclerosis. Methods: A bioinformatic analysis of a dataset from Gene Expression Omnibus (GEO) was performed. A GEO dataset containing data on gene expression levels in samples of atherosclerotic lesions and control arteries without atherosclerotic lesions from carotid, femoral, and infrapopliteal arteries was used for analysis. To evaluate differentially expressed genes, a bioinformatic analysis was performed in comparison groups using the limma package in R (v. 4.0.2) and the GEO2R and Phantasus tools (v. 1.11.0). Results: The obtained data indicate the differential expression of many ABC transporters belonging to different subfamilies. The differential expressions of ABC transporter genes involved in lipid transport, mechanisms of multidrug resistance, and mechanisms of ion exchange are shown. Differences in the expression of transporters in tissue samples from different arteries are established. Conclusions: The expression of ABC transporter genes demonstrates differences in atherosclerotic samples and normal arteries, which may indicate the involvement of transporters in the pathogenesis of atherosclerosis.
Highlights
Atherosclerosis is an important problem for modern mankind [1]
The expression of ATP-binding cassette (ABC) transporter genes demonstrates differences in atherosclerotic samples and normal arteries, which may indicate the involvement of transporters in the pathogenesis of atherosclerosis
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Summary
Atherosclerosis is an important problem for modern mankind [1]. Its medical and social importance is steadily increasing. Disability, and mortality from diseases associated with atherosclerosis carry a heavy economic burden for both patients and their families as well as for public health systems [2]. Studies of the mechanisms of atherosclerosis development are relevant, since early detection and early modification of disturbed processes can be an effective tool for preventing its complications. The results of numerous studies have improved our understanding of the pathogenesis of atherosclerosis. Disruption of cellular transport processes mediated by ABC transporters is known to contribute significantly to the development and progression of atherosclerosis at different stages [3]
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