Abstract
Objectives: To evaluate the analgesic effectiveness of subcutaneous carbon-dioxide insufflations in addition to standard physical treatment in patients with non-specific neck or low back pain. Design: A pragmatic, randomized controlled trial. Setting: Rehabilitation hospital inpatients. Interventions: Patients received either subcutaneous carbon-dioxide insufflations (10 treatments) and standard physical treatment or standard physical treatment only. Outcome measures: Affective pain perception (42-point scale), sensory pain perception (30-point scale), pain intensity (100 mm visual analogue scale). Results: Between-groups differences were –2.2 [95% CI –5.2; +0.9] (affective pain perception), –1.2 [–3, 0; + 0.7] (sensory pain perception), and –6.5 [–14; +1.0] (pain intensity) respectively in favour of subcutaneous carbon-dioxide insufflations. Conclusions: Subcutaneous carbon-dioxide insufflations do not seem to be a worthwile adjunct in the given setting of inpatient rehabilitation. Trials in a monotherapeutic setting, which aim more at the efficacy of subcutaneous carbon-dioxide insufflations, might help to solve this issue.
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