Abstract
Osteoarthrosis is a chronic degenerative disease that involves a high disability rate and creates serious social problems. This study compared the analgesic effect after short-term administration of a keto-profen-lysine salt and acetylsalicylic acid (ASA) as well as the behavior of plasma-circulating beta-endorphin and substance P levels, which appear to be related to the analgesic response in some pathologic conditions. The ketoprofen-lysine salt significantly increased circulating beta-endorphin levels from 30 minutes until 12 hours after administration and reduced substance P levels until 18 hours. Modifications in plasma beta-endorphin and substance P induced by administration of ASA generally were not significant.
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