An unusual case of oral surgical management in a patient with chronic mucocutaneous candidiasis and pure red cell aplasia: A case report

Abstract

Hereditary diseases such as chronic mucocutaneous candidiasis (CMC), autoimmune diseases such as systemic lupus erythematosus (SLE), and chronic secondary diseases such as pure red cell aplasia (PRCA) can make oral/dental surgery for some patients complicated and difficult. Because various comorbidities can increase the risk of complications and reaggravation associated with surgery, there are complexity concerns, challenges, and technical constraints. The comorbid conditions of these intractable diseases can be considered significant risk factors for postoperative complications. Dental disease in a patient with a rare genetic disease with an autoimmune disease and a subsequent refractory disease is an extremely rare case in oral and dental surgery. To our knowledge, few reports have investigated appropriate peri- and preoperative management strategies to minimize risk for postoperative complications. Therefore, informed contemplation is required to perform safe and effective surgical therapy for such patients. This case report aimed to present the experience of managing a 24-year-old woman having multiple dental caries comorbid with rare diseases, including CMC, PRCA, and SLE, and a brief overview of the symptoms and possible complications of the patient's comorbidities. In this case, local antifungal drugs, blood transfusion, and antibiotic treatment were administered before surgery to improve the oral environment and reduce the risk of infection and delayed wound healing. Furthermore, general anesthesia was applied to surgically remove caries. The patient was treated with intensive medication and wound management and recovered without postoperative complications after 1 year of follow-up. (237words)