Abstract

AbstractLipids can be systematically classified according to functional properties, structural features, biochemical origin or biological system. However Lipid nomenclature has yet to become a robust research tool since no rigorous definitions exist for membership of specific lipid classes. Lipids need to be defined in a manner that is systematic yet at the same time semantically explicit. We report on the reuse of existing lipid nomenclature, ontology describing chemical structure and the extension of the OWL-DL Lipid Ontology to support the classification of lipid molecules. We applied definitions, DL-axioms, to describe lipids classes and illustrate suitability of the ontology for the classification of Fatty Acyl lipids and Mycolic acids.

Highlights

  • IUPAC-IUBMB proposed a systematic nomenclature for lipids which received limited adoption by the lipid community

  • We report on the reuse of existing lipid nomenclature, ontology describing chemical structure and the extension of the OWL-Description logics (DL) Lipid Ontology to support the classification of lipid molecules

  • In this paper we have sought to address the ongoing challenge of classifying lipids through the adoption of W3C standard knowledge representation and the application of DL axioms

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Summary

Introduction

IUPAC-IUBMB proposed a systematic nomenclature for lipids which received limited adoption by the lipid community. We report on the reuse of existing lipid nomenclature, ontology describing chemical structure and the extension of the OWL-DL Lipid Ontology to support the classification of lipid molecules. DL-axioms, to describe lipids classes and illustrate suitability of the ontology for the classification of Fatty Acyl lipids and Mycolic acids. We can define necessary and sufficient conditions limiting the definition of an alpha mycolic acid to a lipid that has only alpha-hydroxyl acid and cyclopropane functional groups.

Results
Conclusion

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