An Overview of Cinnolines, Quinazolines and Quinoxalines: Synthesis and Pharmacological Significance

Abstract

Over the past two centuries, fused N-heterocyclic compounds are extensively utilized as valuable entities for the expansion of pharmacological significant agents and deliberated as one of the advantaged scaffolds. Among the numerous fused N-heterocyclic compounds, cinnoline, quinoxalines and quinazolines are significant pharmacological agents, and a noteworthy amount of study has been conducted regarding this type of compounds. In medicinal chemistry, these N-heterocyclic compounds have broad range of biological properties and used as synthetic intermediates, potential drug candidates and chemical probes. Since they are indispensable moieties to treat infectious diseases, in the past years, there is a surge in the significance of designing innovative cinnoline, quinoxalines and quinazolines derivatives, sightseeing auspicious methods to access these moieties, examining their different properties and potential applications. The aim of this chapter is to highpoint the topical studies made by chemist on numerous biological activities and synthetic methods of cinnoline, quinoxalines and quinazolines via sustainable synthetic approaches described in the literature. It would buoyantly be useful for the researchers who have fascinates in evolving innovative therapeutic agents and associated valuable chemical probes.