Abstract
Objective: Objective of the study was to investigate the safety, efficacy, and antipsoriatic activity of topical cream enriched with Nanostructured Lipid Carriers (NLC) of Azadirachta indica, Lawsonia inermis, and Mallotus philippensis through the controlled clinical study. Methods: The randomized controlled trial was performed for 12 months on 65 adult patients between the age group 20 and 60 years of either sex of diagnosed, uncomplicated cases of psoriasis Vulgaris. The Test group received a local application of the herbal antipsoriatic NLC enriched cream, while the Control group was treated with Clobetasol propionate 0.05% cream twice daily for 3 months. Both groups were assessed for parameters of skin and nail examinations, lab investigation, and Psoriasis Area and Severity Index (PASI) score. The data were analyzed and interpreted statistically. Results: Significant improvement in itching and PASI score was seen during successive visits in both groups. However, recurrence of mild itching and erythema in a few patients of the control group was seen after 2 weeks, whereas no such recurrence is seen in the test group. Statistically significant reduction in eosinophilia in the control group was observed before and after treatment. The efficacy of clobetasol in the control group and the prepared formulation in the test group both show statistical efficacy at par. Conclusion: The data suggest that the NLC enriched cream exhibited significant relief in all the symptoms of psoriasis and therefore can be used as a potent antipsoriatic agent due to the easy availability of the drugs and cultural affinity for herbal formulations.
Highlights
Psoriasis (Taqashshur-e-Jild) is a chronic inflammatory skin disorder characterized by red, scaly, and raised patches
The authors have investigated the safety, efficacy, and antipsoriatic activity of topical cream enriched with Nanostructured Lipid Carriers (NLC) of A. indica, L. inermis,and M. philippensis through a randomized controlled trial was performed for 12 months on 65 adult patients between the age group 20 and 60 years of either sex of diagnosed, uncomplicated cases of psoriasis Vulgaris
Intending to evaluate clinical safety and efficacy of classical Unani medicines prescribed by Hakims and to formulate Lipid-Based Nano-particulate Topical Drug Delivery System in the treatment of Taqashshur-e-Jild (Psoriasis) using various modern scientific parameters, the objective of the present study was to: assess the efficacy and safety of Unani Anti-Psoriatic cream in uncomplicated cases of psoriasis, controlled clinical study of topical nanoparticulate antipsoriatic Unani formulation with that of Clobetasol propionate 0.05% cream was performed on the human volunteers with the statistical presentation, analysis, and interpretation after applying appropriate tests of significance to compare the safety and efficacy of nanoparticulateUnani antipsoriatic formulation and Clobetasol propionate 0.05% cream
Summary
Psoriasis (Taqashshur-e-Jild) is a chronic inflammatory skin disorder characterized by red, scaly, and raised patches. The literature survey supports an anti-inflammatory activity of Azadirachta indica leaves, Lawsonia inermis leaves, and fruit of Mallotus philippensis and has been used in combination in traditional medicine in the treatment of psoriasis [3]. The antipsoriatic potential of the A. indica leaves extract (AE), L. inermis leaves extract (LE) and fruit extract of M. philippensis (ME) enriched Nanostructured Lipid Carriers (NLCs) and their cream formulation has been reported and discussed in our previous work [3-5]. The authors have investigated the safety, efficacy, and antipsoriatic activity of topical cream enriched with NLC of A. indica, L. inermis,and M. philippensis through a randomized controlled trial was performed for 12 months on 65 adult patients between the age group 20 and 60 years of either sex of diagnosed, uncomplicated cases of psoriasis Vulgaris
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