Abstract
Objective: The aim of the present study was to investigate the clinical and nutritional factors influencing the renal function of the transplanted kidney during a one-year follow-up period after transplantation. Patients: The present prospective observational study included 52 patients who underwent kidney transplantation at Jichi Medical University Hospital from 2014 to 2016. Results: The serum creatinine (sCr) concentration at one month after transplantation was closely related to the concentration at 12 months. The recipients were divided into two groups based on the sCr concentration at one month after transplantation. Recipients with a sCr concentration greater than or equal to the median were classified into Group H, while those with concentrations that were less than the median were classified into Group L. A stepwise multiple regression analysis demonstrated that the salt intake in male recipients was an independent predictor of the renal function at 12 months (β = 0.663, p β = 0.618, p < 0.01). Moreover, in female recipients, the BMI and serum uric acid values in Group H were significantly higher than those in Group L. The BMI values of the female recipients in Group H were significantly higher than those in Group L at all times during the follow-up period (p < 0.01). Conclusion: The daily salt intake was independently associated with the renal function at one year after kidney transplantation in male recipients. In female recipients, the BMI was independently associated with the sCr concentration during the one-year follow-up period.
Highlights
Patients with end-stage kidney disease (ESKD) are usually treated with hemodialysis, peritoneal dialysis or kidney transplantation
Recipients with a serum creatinine (sCr) concentration greater than or equal to the median were classified into Group H, while those with concentrations that were less than the median were classified into Group L
Recipients whose serum Cr concentrations were greater than or equal to the median were classified into Group H, while those whose values were less than the median were classified into Group L
Summary
Patients with end-stage kidney disease (ESKD) are usually treated with hemodialysis, peritoneal dialysis or kidney transplantation. Kidney transplantation is superior to the other treatments as it benefits the quality of life and improves the prognosis with regard to cardiovascular complications. In Japan, the number of kidney transplants has been increasing since cyclosporine, a potent immunosuppressant, was introduced in the clinical setting. In 2015, 1,661 patients received kidney transplants in Japan, and the number of living and deceased donor reached 1494 and 167, respectively [1]. Kidney transplant recipients are usually managed with special care during the follow-up period (i.e., the early post-operative phase of 1 - 2 weeks, the early post-transplant follow-up phase of 3 - 4 months, and the long-term follow-up phase). During the long-term follow-up phase, the risk of infection or acute rejection decreases with the stability of the renal function because the self-defense system is rebuilt in the recipient
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