Abstract
The emergence of antibiotic-resistant “superbugs” in recent decades has led to widespread illness and death and is a major ongoing public health issue. Since traditional antimicrobials and antibiotics are in many cases showing limited or no effectiveness in fighting some emerging pathogens, there is an urgent need to develop and explore novel antibacterial agents that are both powerful and reliable. Combining two or more antibiotics or antimicrobials has become a hot topic in antibacterial research. In this contribution, we report on using a simple electrospinning technique to create an N-halamine/graphene oxide-modified polymer membrane with excellent antibacterial activity. With the assistance of advanced techniques, the as-obtained membrane was characterized in terms of its chemical composition, morphology, size, and the presence of active chlorine. Its antibacterial properties were tested with Escherichia coli (E. coli) as the model bacteria, using the colony-counting method. Interestingly, the final N-halamine/graphene oxide-based antibacterial fibrous membrane inactivated E. coli both on contact and by releasing active chlorine. We believe that the synergistic antimicrobial action of our as-fabricated fibrous membrane should have great potential for utilization in water disinfection, air purification, medical and healthcare products, textile products, and other antibacterial-associated fields.
Highlights
Infectious diseases arising from pathogenic bacteria have become one of the leading causes of death worldwide, especially with the emergence of antibiotic resistance in pathogenic bacteria [1,2,3]
It has been widely recognized that the emergence of antibiotic resistance in pathogenic bacteria is largely due to the misuse and overuse of antibiotics, resulting in the increasing failure of traditional antibiotics [6,7]
When DCDMH and graphene oxide (GO) were mixed with PAN, followed by electrospinning, the as-obtained products (Figures 2D and 3F) exhibited a fiber-based morphology coupled with well-dispersed nanosheets on the fibrous membrane
Summary
Infectious diseases arising from pathogenic bacteria have become one of the leading causes of death worldwide, especially with the emergence of antibiotic resistance in pathogenic bacteria [1,2,3]. It has been widely recognized that the emergence of antibiotic resistance in pathogenic bacteria is largely due to the misuse and overuse of antibiotics, resulting in the increasing failure of traditional antibiotics [6,7]. Unlike some antibacterial agents that kill bacteria via a single pathway, N-halamines can transfer an active halogen to bacterial receptors on contact or by releasing the active halogen (e.g., Cl+) [15]. Such a contact/release combined antibacterial mode enables N-halamines to be active in both wet and dry environments [16]
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