Abstract
The behavioral effects of histamine agonists and antagonists were investigated in mice subjected to handling, injections, and transport to a novel observation chamber. Relative to control mice subjected to this treatment, mice treated with various doses of an H1 histamine receptor agonist or an H2 receptor antagonist displayed significantly elevated levels of grooming. On the other hand, treatments with either an H1 histamine antagonist or H2 receptor agonist attenuated stress-induced grooming. These effects of histaminergic agents were probably not due to their general effects on behavioral arousal, but rather may be specific to neurohumoral mechanisms mediating grooming. We have postulated that H1 histamine receptor activation is involved in the excessive grooming induced by the stressor of being handled and placed in a novel environment, whereas H2 receptor activation attenuates this phenomenon via inhibitory control of H1 histamine neural elements.
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