Abstract
Low-grade cribriform cystadenocarcinoma (LGCCA) is a rare tumor of the salivary gland that exhibits clinically indolent behavior. In this paper, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that exhibited histology suggestive of an association of LGCCA. A 27-year-old man presented with a subcutaneous tumor in his left cheek. The tumor was separated from the parotid gland and located on the masseter muscle. The tumor was resected, and the postoperative histological diagnosis was adenocarcinoma, not otherwise specified (ANOS). The tumor exhibited papillary-cystic and cribriform proliferation of the duct epithelium and obvious stromal infiltration. Some tumor nests were rimmed by myoepithelium positive for smooth muscle actin, p63, and cytokeratin 14, indicating the presence of intraductal components of the tumor. Tumor cells exhibited mild nuclear atypia, and some of them presented an apocrine-like appearance and had cytoplasmic PAS-positive/diastase-resistant granules and hemosiderin. Other cells had foamy cytoplasm with microvacuoles. Immunohistochemistry revealed that the almost all of the tumor cells were strongly positive for S-100. These histological findings suggest the possibility that ANOS might arise secondarily from LGCCA. This is an interesting case regarding the association between ANOS and LGCCA in oncogenesis.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1226764594634693.
Highlights
Delgado et al originally described low-grade cribriform cystadenocarcinoma (LGCCA) as a rare low-grade variant of salivary duct carcinoma (SDC) in 1996 [1]
As the tumor was located on the masseter muscle and a histologically normal salivary gland was observed in the periphery of the tumor, the tumor might have developed from the accessory parotid gland
Neoplasms arising from an accessory parotid gland are relatively rare, and variable types of malignant tumor have been reported in the literature: carcinoma ex pleomorphic adenoma [12], squamous cell carcinoma [13], mucoepidermoid carcinoma [14], acinic cell carcinoma [15], oncocytic carcinoma [16], basal cell carcinoma [14], and small cell carcinoma [14]
Summary
Delgado et al originally described low-grade cribriform cystadenocarcinoma (LGCCA) as a rare low-grade variant of salivary duct carcinoma (SDC) in 1996 [1]. * Correspondence: nakatsuka@kanrou.net 1Department of Pathology, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo 660-8511, Japan Full list of author information is available at the end of the article similar to an invasive ductal carcinoma of the breast [10,11]. We present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that had left vestiges of LGCCA in its histology.
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