Abstract
Calcium is a ubiquitous second messenger. Mitochondria contributessignificantly to intracellular Ca2+ dynamics. Theexperiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465]demonstrated that inhibiting mitochondrial Ca2+ uptake canreduce the frequency of cytosolic Ca2+ concentrationoscillations of gonadotropes. By considering the mitochondrialCa2+ cycling we develop a three-variable model ofintracellular Ca2+ oscillations based on the models ofAtri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J.77 (1999) 37]. The model reproduces the fact that mitochondrialCa2+ cycling increases the frequency of cytosolicCa2+ oscillations, which accords with Kaftan's results.Moreover the model predicts that when the mitochondria overload withCa2+, the cytosolic Ca2+ oscillations vanish,which may trigger apoptosis.
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