Abstract
Acidification of blood entering the membrane lung (ML) converts bicarbonate ions into dissolved gaseous CO2, increasing the pCO2 transmembrane gradient and thus the extracorporeal carbon dioxide removal (ECCO2R) [1]. Extracorporeal blood acidification has previously been achieved by infusion of lactic acid, which proved to be effective in rising ECCO2R but determined a mild increase of total CO2 production and induced a slight degree of metabolic acidosis [2], thus limiting the overall effectiveness of such treatment.
Highlights
Acidification of blood entering the membrane lung (ML) converts bicarbonate ions into dissolved gaseous CO2, increasing the pCO2 transmembrane gradient and the extracorporeal carbon dioxide removal (ECCO2R) [1]
The aim of this study is to evaluate in-vitro the efficiency of an ECCO2R technique enhanced by an innovative acidification system featuring an electrodialysis unit, which does not require the infusion of any exogenous acid
At the end of each step samples were withdrawn from blood and dialysiscircuit, and CO2 removal (VCO2) was measured
Summary
Acidification of blood entering the membrane lung (ML) converts bicarbonate ions into dissolved gaseous CO2, increasing the pCO2 transmembrane gradient and the extracorporeal carbon dioxide removal (ECCO2R) [1]. Extracorporeal blood acidification has previously been achieved by infusion of lactic acid, which proved to be effective in rising ECCO2R but determined a mild increase of total CO2 production and induced a slight degree of metabolic acidosis [2], limiting the overall effectiveness of such treatment
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