Abstract
Neuroscience Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of the NMDA receptor subunit combination GluN1/GluN3A in the medial habenula (MHb) of adult mice. This NMDA receptor subunit combination in MHb neurons is activated by glycine released from astrocytes. Activation of GluN1/GluN3A NMDA receptors causes depolarization and increased spiking of MHb neurons. Reducing GluN3A receptor subunit levels in the MHb blocks conditioned place aversion. Science , this issue p. [250][1] [1]: /lookup/doi/10.1126/science.aax1522
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