Abstract
Intraperitoneal administration of 0.8 mg/kg N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinole (EEDQ) to rats significantly reduced α-adrenoceptor binding in cerebral cortical membranes without affecting β-adrenoceptor sites. A selective reduction in α 1-adrenoceptors was achieved by injecting yohimbine prior to EEDQ, whereas prazosin pretreatment yielded a selective reduction in α 2-adrenoceptor binding. Administration of EEDQ decreased norepinephrine-stimulated phosphate and cyclic adenosine monophosphate (cAMP) accumulation in cerebral cortical tissue as well as the cAMP response to isoproterenol in combination with 6-fluoronorepinephrine without modifying the second messenger response to isoproterenol alone. The results suggest that, under the proper conditions, EEDQ administration can selectively diminish rat brain α-adrenoceptor number and function, yielding a procedure that may be useful for defining the behavioral and physiological properties of these sites.
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