Abstract
Antibiotic resistance among bacterial pathogens especially gram-negative bacteria has risen markedly over the last decade. Inadequacy of the commercial antibiotics against multidrug resistant strains of bacteria has necessitated the search for effective antimicrobials from lesser explored ecosystems. Recently, cave actinomycetes have drawn considerable attention as a source of novel antibacterial agents. Garhwal Himalayan region in Uttarakhand abodes several pristine caves which have not been previously explored for their actinomycetes diversity. The present study has been designed to have an insight into the bioactive spectrum of cave actinomycetes of Garhwal Himalaya. In the present study, a total of 103 actinomycetes were isolated from three distinct caves. Streptomyces sp. was found to be the predominant species in all the samples. The recovered actinomycetes were screened for their antibacterial activities with a focus on their activity against MDR E. coli, A. baumannii, S. pyogens, MRSA and VRE. faecalis. Isolates RCM1, RCM14 and SCM1 showed significant antibacterial activities. SCM1 was found to be most promising isolate exhibiting remarkable inhibition against MDR bacterial pathogens.
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