Abstract

AbstractAn improved procedure has been developed for the Rieche formylation of substituted benzenes using dichloromethyl methyl ether and silver trifluoromethanesulfonate. This reaction proceeds smoothly at low temperatures (−78 to 0 °C) over short reaction times (10–30 min), and allows for the formylation of various aromatic compounds to afford the corresponding aldehydes in one step. Notably, this protocol was tolerant towards a wide range of phenol-protecting groups, including benzyl, methyl, allyl and propargyl ethers, whereas conventional Rieche conditions induced the partial deprotection of these groups.KeywordsRieche formylationDichloromethyl methyl etherSilver trifluoromethanesulfonateBenzaldehyde

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