Abstract
Bacterial biofilms have been implicated with breast implant complications including capsular contracture, double-capsule formation, and breast implant-associated anaplastic large cell lymphoma. However, the relationship between implant surface texture and microbial biofilm formation is insufficiently evaluated. In the present study, we examined the antimicrobial activities of different types of silicone breast implant. The growth of bacterial including Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa was compared using implants with various surface textures, including Hans Smooth, Hans SmoothFine, Allergan Smooth, Eurosilicone Smooth, Eurosilicone Texture, Sebbin Smooth, Sebbin Micro, Sebbin Texture, and Motiva Smooth. Microbial investigation revealed the increased growth of S. aureus on breast implants after 48 h, except Eurosilicone Smooth, Eurosilicone Texture, Hans SmoothFine and Sebbin Smooth material. At 48 hours, there was no major difference between the S. aureus attachment on smooth and textured implants. The results of S. epidermis attachment on the implant after 48 h showed that their growth decreased on surfaces of Motiva Smooth, Sebbin Smooth, and Eurosilicone Smooth. These results indicated that S. epidermis was unable to survive on these breast implants. Eventually, P. aeruginosa count had showed decrease of bacterial count after 48 hours compared to 24 hours in most of the implants except for Eurosilicone Texture, Sebbin Smooth and Sebbin Micro, where the count of P. aeruginosa slightly increased. This indicated that P. aeruginosa was unable to exist on the smooth surfaces. Our results show that the in vitro assay revealed no significant difference between smooth and textured surfaces and showed variable interactions and needed further molecular analysis to assess their adherence nature.
Highlights
Silicone is the most familiar and popular pharmaceutical agent used in the human body because of its molecular and physical properties [1]
General similarities among the groups of textures have been noticed in Hans Smooth, Eurosilicone Smooth, Sebbin Smooth and Allergen Smooth (Figure 1)
Despite the bacterial response depending on several issues, implant surface topography significantly elucidates the consequences of bacterial attachment
Summary
Silicone is the most familiar and popular pharmaceutical agent used in the human body because of its molecular and physical properties [1]. It gains more popularity as breast implant over the years for the reconstructive as well as aesthetic attribution. Silicone implant for long-term transplantation causes capsule contracture (CC) that is undesirable after surgery [2]. It entails contracting the collagen capsule formed around the breast, which may be uncomfortable and can distort the breast structure frequently [3]. Bacterial biofilms were associated with complications in breast implants, including CC and large-cell anaplastic lymphoma [4]
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