Abstract
Prediction of the safety or hazard of various exposures to mixtures of chemicals must often be made in the absence of knowledge of the mode of their joint toxic action. The rat peroral LD50 was determined for 50% by volume mixtures of all possible pairs among 27 commercial organic chemicals. The results indicate that the harmonic mean formula for additive joint toxicity satisfactorily predicted the toxicity of a large proportion of the pairs. The soundest hypothesis for the joint action of untested pairs is that of additive toxic action. Pairs deviating most markedly from this mode of joint action are listed.
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