Abstract
I N 196~ Clarke et al. 1 introduced micropaque barium sulphate, a sterile suspension of barium sulphate, the particles varying in size between 0.5/~ to below 0.1 g, as a substitute for thorium dioxide in the radiographic marking of cerebral abscesses. They used this material in 8 patients with cerebral abscesses and reported that microbarium was superior to thorium dioxide. They believed that because microbarium was inert chemically it would be a safe material in brain tissue as well as in the ventricular system or subarachnoidal spaces. The purpose of the present investigation was to determine the reactivity of micropaque barium sulphate in brain tissue, the cerebral ventricles, the subarachnoidal spaces, and in artificially induced cerebral abscesses.
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