Abstract
The structural basis of the affinity of zinc iodide-osmium stain to nerve terminals was examined with the aid of the electron microscope at the mammalian subfornical organ and myoneural junction. It turned out that this affinity is based on the selective staining of synaptic vesicles, whose content forms an electron-opaque reaction product. The synaptic membranes, the basement membranes of junctional folds and the mitochondria remain indifferent. Certain types of synaptic vesicles gave equally negative results: (1) 800–1500Ådark-cored vesicles in nerve terminals of the subfornical organ and (2) large populations of agranular spheric vesicles within spinal cord nerve terminals. These data may indicate some degree of specificity with respect to vesicular content. The possible relationship of this staining method to mechanisms of cholinergic transmission is mentioned.
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