An efficient solvent free multicomponent synthesis of functionalized 4H-chromenes by using reusable, heterogeneous Amberlite IRA-400 Cl resin as catalyst

Abstract

A simple and efficient Amberlite IRA-400 Cl resin catalyzed multicomponent reaction of 2-hydroxy-1-naphthaldehyde, 1,3-diketone, and nucleophile under solvent free condition to obtain the biological important 4H-chromene derivatives has been outlined. Significant features of this method are the simplicity of the procedure, the ready accessibility, and cost effectiveness of the catalyst, and higher yields in a relatively short reaction time. Structures of compounds 4j and 5c were confirmed from single crystal X-ray studies.