Abstract
A series of spiro[acenaphthylene-1,2′-pyrrolidine] derivatives ( 4a-j ) were synthesized by highly efficient one-pot three-component reaction of acenaphthenequinone, sarcosine and Knoevenagel adduct in 2,2,2-trifluoroethanol as a reusable green solvent. All the synthesized compounds were screened for their ‘in vitro’ antimalarial activity against the growth of Plasmodium falciparum , the malaria causing parasite. Some of them showed antimalarial activity with IC 50 values as low as 0.003 and 0.005 mg/mL. The compounds were evaluated for their antibacterial activity against Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa and Streptococcus pyogenes and for antifungal activity against Candida albicans , Aspergillus niger , and Aspergillus clavatus . Some of the compounds exhibited excellent antibacterial activity and compounds 4c and 4e demonstrated significant antifungal activities than the standard drugs.
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