Abstract
AbstractIn this investigation, the preparation of the chiral intermediate, (R)‐1‐(2‐chlorophenyl)‐2‐(2 H‐tetrazol‐2‐yl)ethan‐1‐ol (2 a), a precursor to the anti‐epileptic drug Cenobamate, was demonstrated using a very efficient alcohol dehydrogenase (ADH) enzyme from a simple ketone substrate. The enzyme, ADH107604 from Streptomyces coelicolor (ScADH), identified from Dr. Reddy's in‐house collection of biocatalysts, showed excellent activity against the ketone 1‐(2‐chlorophenyl)‐2‐(2 H‐tetrazol‐2‐yl)ethan‐1‐one 1, and the (R)‐alcohol product 2 a was obtained with excellent conversion and enantiomeric excess (ee) >99 %.
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