Abstract
K2CO3-NaHCO3-mediated conjugate-addition-initiated ring-closure (CAIRC) reaction of various active methylene compounds to 2-bromo-2-cyclopentenone in the presence of [BMIM]PF6-H2O (2:1) producing carbocyclic and heterocyclic compounds is described. The use of [BMIM]PF6-H2O as a solvent for CAIRC reaction is advantageous offering simple product isolation and shorter reaction times compared to conventional solvents. This reaction system can provide a general and practical method for the construction of 2,2-disubstituted cyclopropanes and polycyclic dihydrofuran derivatives containing electron-deficient substituents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
