Abstract
Objectives: It is known that many conditions may impact on dental organ development at foetus or new-born stages. The most important influence in this case is caused by genetic predispositions but also by drugs delivered prenatally and postnatally to the organism. The goal of this research was to find if the applications of Zidovudine to mothers’ organisms of rats can caused some abnormalities in dental organs of new-borns. Methods: The study was performed on 20 Wistar female rats and their 36 new-borns bred. The group of adult pregnant rats was divided on two sub-groups: with and without Zidovudine receiving. The influence of Zidovudine administered was assessed by using the quantitative laser-induced fluorescence and compared with the group without Zidovudine receiving as a reference subjects. Results: In result the dependences in Zidovudine receiving were obtained and the changes in tissues were detected by use the laser fluorescence method. Moreover the differences between groups with and without Zidovudine are obtained in morphological results. The stronger impact of drug was obtained for mothers rats than new-borns. Conclusions: All obtained results show usefulness laser fluorescence in dental organ assessment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
