Abstract

The diagnosis of vasovagal syncope is made with accurate histories, tilt testing, and implantable loop recorders. However, ambiguous histories, inaccurate tests, unwillingness to delay a diagnosis, and limited expertise have been barriers to successful utilization of these approaches. A circulating biomarker might be useful to facilitate diagnoses. Previous literature suggests that endothelin-1 may be elevated in vasovagal syncope, and vasopressin increases during positive tilt tests. Copeptin is a stable cleavage product of vasopressin formation. We conducted a pilot-study to assess the utility of Endothelin-1 and Copeptin as potential biomarkers of vasovagal syncope.

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