Abstract
Transfer RNA from the nematode Turbatrix aceti was examined for age-related changes in isoaccepting forms for sixteen amino acids. This was considered to be an index for possible changes at the translational level of protein synthesis. Aged T. aceti were obtained by the use of hydroxyurea to block reproduction, and their tRNA was purified. This was compared by reverse phase chromatography with tRNA from young T.aceti exposed to hydroxyurea for a short time. Chromatography revealed single peaks for the tRNA of seven amino acids and multiple peaks for tRNA of nine. Of these, only the tRNA for arginine any tyrosine showed consistent age-related differences, which were not attributable to either any decrease in mitochondria in old worms or the presence of eggs in only the control worms. The changes were not due to a general short-term effect of hydroxyurea.
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