An Analysis of HPV Infection and Distribution in Cervical and Genital Samples With Condyloma Acuminatum: A Retrospective Study

Abstract

Objective: Human papillomavirus (HPV) causes condyloma acuminata, which is one of the most widespread sexually transmitted diseases. This study was aimed to evaluate the prevalence of HPV infection and HPV genotype distribution in patients with condyloma acuminatum in Urumqi, China. Methods: A total of 835 cervical and genital samples were collected from outpatients treated for condyloma acuminatum between December 2016 and December 2018. HPV genotyping was performed with the HPV Genotyping Real-time PCR Kit for 23 different HPV types. Statistcal analysis was conducted using the chi-square test. Results: The total prevalence of HPV infection was 80.72% (674/835) in patients with condyloma acuminatum in Urumqi. The HPV genotypes were HPV-6 (372/835, 44.55%), HPV-11 (180/835,21.56%), HPV-16 (91/835,10.90%), HPV-43 (65/835, 7.78%), HPV-42 (56/835, 6.71%), and HPV-58 (53/835, 6.35%). Among HPV-infected individuals, 49.11% (331/674) were infected by a single HPV subtype, while 50.89% (343/674) were infected by multiple HPV subtypes. The prevalence of HPV infection was higher in females (82.14%, 276/336) than in males (79.76%, 398/499) (χ 2 = 0.73, P=0.39), and higher in other ethnicities (86.36%, 133/154) than in people of Han ethnicity (79.76%, 541/ 681) (χ 2 = 3.866, P=0.049). The peak prevalence of HPV infection was observed in the age groups of 20–29 years and 30–39 years. Conclusion: HPV infection was detected in most patients with condyloma acuminatum in Urumqi with prevalence of 80.72%, and the most common HPV types were HPV-6, -11, -16, -43, -42, and -58. The detection of HPV genotypes is very important to monitor HPV infection so that effective treatment is administered to patients with condyloma acuminatum.