Abstract
Dopamine induces a decrease in voltage-dependent Ca 2+ current in identified neurons of the snail H. aspersa. This effect is blocked by intracellular injection of activated B. pertussis toxin and of an affinity-purified antibody against the a subunit of bovine G 0. protein. The dopamine effect is mimicked by intracellular injection of mammalian α 0. In snail nervous tissue, pertussis toxin ADP-ribosylates a single protein band on SDS gels, and this band is recognized in immunoblots by the anti- α 0 antibody. We propose that this is a 40 kd a subunit of a molluscan G protein immunologically related to α 0 and that it mediates the effect of dopamine on Ca 2+ currents in identified snail neurons.
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