Abstract
Introduction: The postischemic myocardium is protected from cardiomyocyte loss, progressive heart failure and mitochondrial dysfunction by caloric restriction (CR). Recent data demonstrate that some CR effects are mediated by AMP-activated protein kinase (AMPK) activation by adipokines. Novel therapeutic options that mimic effects of CR, in addition to established heart failure therapy may improve myocardial function and outcome of heart surgery patients. Here, we investigated the effects of CR in an experimental model of afterload-induced cardiac dysfunction (aortic banding) on cardiac and mitochondrial function, apoptosis as well as adipokine-mediated activation of AMPK.
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