Abstract
Abstract Amphiphilic heme derivatives having four steroid groups (steroid-heme), 5,10,15,20-tetrakis[α,α,α,α-o-[2,2-dimethyl-8-(3α-hydroxycholan-24-oyloxy)octanamido]phenyl]porphinatoiron (1b) and 5,10,15,20-tetrakis[α,α,α,α-o-(3-acetoxycholan-24-oylamino)phenyl]porphinatoiron (2b), were synthesized as a model of an oxygen carrier. They were efficiently embedded in the bilayer of a phospholipid liposome based on their high compatibility with the lipid. The oxygen-binding ability of 1b was compared with those of hemoglobin (Hb) and myoglobin (Mb). The dioxygen adduct of 1b was also characterized by Mössbauer and infrared spectroscopy.
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