Abstract
Herein, poly(ethylene glycol)-block-poly(ɛ-caprolactone) (PEG114-b-PCLx) copolymer is employed to enhance the water solubility of fashionable photoinitiator, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide (TPO). PEG114-b-PCLx copolymers are first polymerized via the conventional ring-opening polymerization. Subsequently, TPO encapsulated nanoparticles (TPO@PEG114-b-PCLx) are prepared through the nanoprecipitation method, followed by a water removal process using lyophilization. By altering the PEG114-b-PCLx molecular weights and TPO: PEG114-b-PCLx ratios, the resulting nanoparticles exhibited hydrodynamic average sizes ranging from 190 to 360 d.nm with the TPO encapsulation efficiency of approximately 21–35%. Afterward, these prepared photoinitiators were formulated with poly(ethylene glycol dimethacrylate) (PEGDMA) and methacrylate-functionalized dextran (Dex-MA) before fabricating the 3D-printed hydrogels through digital light processing (DLP). The compressive moduli of the hydrogels covered from 0.13 to 1.79 MPa, depending on the content of PEGDMA and Dex-MA and the degree of substitution of Dex-MA. The cytotoxicity results of printed specimens revealed that the hydrogels are noncytotoxic to chondrocyte and fibroblast.
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