Abstract
Dermatophytes were earlier reported to respond well to anti-fungal agents; however, an upsurge in resistance with the high cost of these agents increased the use of medicinal plants for treatment. This study investigated the sensitivity pattern of dermatophytes to oral anti-fungal drugs and aqueous leaf extract of the plant, Acacia nilotica. The extract was tested against seven strains of dermatophytes Arthroderma otae, Trichophyton interdigitale, Trichophyton mentagrophyte, Microsporum ferrugineum, Arthroderma vespertilii, Arthroderma quadrifidum, and Arthroderma multifidum, previously isolated from diabetic patients. The minimum inhibitory and fungicidal concentrations of the plant extracts and the standard antifungal agents were evaluated using modifications of the broth macro dilution method of the National Committee for Clinical Laboratory Standards M38-A2 protocol. There was a significant difference in the Minimum Inhibitory concentrations (MIC) of the dermatophytes to the three antifungal drugs tested (p Acacia nilotica had an inhibitory effect on all the dermatophytes tested, and showed anti-fungal activity in a dose-dependent relationship between 0.625 - 1.25 mg/ml. Though the inhibitions of the dermatophytes were significantly higher with the standard anti-fungal drugs as compared to the plant extract (p Arthroderma quadrifidum, which was resistant to all the anti-fungal drugs, had the highest inhibition with A. nilotica. Some circulating dermatophyte strains in Nigeria are griseofulvin and/or itraconazole resistant which may influence the spread of infection and A. nilotica aqueous leaf extract showed a strong anti-dermatophytic activity.
Highlights
Dermatophytosis is a fungi infection that affects the skin, hair, and nails
Dermatophytes can survive over a year in optimal humid and high temperature environments [tropical and sub-tropical regions], and socioeconomic factors and migrations influence the transmission of infection, making dermatophytosis the most prevalently diagnosed skin disease in Africa [5]
All the dermatophytes tested in this study were resistant to griseofulvin, and even dermatophytes resistant to itraconazole, nystatin and griseofulvin were susceptible to the A. nilotica leaf extract (Table 1)
Summary
Dermatophytosis is a fungi infection that affects the skin, hair, and nails. Dermatophytosis is called tinea based on the infection site. Dermatophytosis is typically caused by dermatophytes, which are one of the most common fungal agents, belonging to the Microsporum, Trichophyton, or Epidermophyton genera, causing superficial skin infection globally [1,2,3,4]. The transmission of dermatophyte infection is mainly through contact with contaminated hair coats of animals and insects such as fleas or houseflies [3]. Dermatophytes can survive over a year in optimal humid and high temperature environments [tropical and sub-tropical regions], and socioeconomic factors and migrations influence the transmission of infection, making dermatophytosis the most prevalently diagnosed skin disease in Africa [5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
