Abstract
Garcinia mangostana, commonly known as mangosteen, is a tropical fruit with a reddish-purple pericarp. In Southeast Asia, the pericarp has traditionally been used as a medicine to treat various diseases, including inflammation, wounds, and bacterial infections, as well as aging. α-mangostin is an abundant xanthone in the pericarp, and is thought to play a critical role in the medicinal effects of mangosteens. Previous studies have demonstrated numerous beneficial effects of α-mangostin, such as cytotoxicity in cancer cells. However, the effects of this xanthone in in vivo have not yet been studied. In the current study, C. elegans was used to test the in vivo effects of α-mangostin using several bioassays, including fat accumulation, pharyngeal movement (pumping) and heat-stress assays. Quantitative real time PCR (qRT-PCR) was also used to examine the expression of heat shock proteins. The results revealed that α-mangostin appeared to cause an increase in fat accumulation, which correlated with an increase in pharyngeal movement. The thrashing movement of the worms after heat stress also showed a correlation with an increase in heat shock protein mRNA expression.
Highlights
Garcinia mangostana Linn., commonly known as mangosteen, belongs to the Guttiferae family and is known as “the queen of fruits”
The results revealed that α-mangostin appeared to cause an increase in fat accumulation, which correlated with an increase in pharyngeal movement
The results show that α-mangostin induced the lipid accumulation dose-dependently (Figure 1(a))
Summary
Garcinia mangostana Linn., commonly known as mangosteen, belongs to the Guttiferae family and is known as “the queen of fruits”. It is native to and most cultivated in tropical areas, in Southeast Asian countries such as Indonesia, Malaysia, The Philippines, and Thailand In these countries, mangosteens, especially the pericarp, have traditionally been used as a medicine for the treatment of diseases such as abdominal pain, urinary tract infections, and in-. Mangosteens are widely used to treat many health conditions, there is little scientific evidence to support their effectiveness in humans. At this time, α-mangostin has been extensively studied using in vitro models, such as cell culture, but in vivo studies using real animals have not been reported [8]. The aim of the present study was to examine the physiological effects of α-mangostin using in vivo experiments
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